Stomach cancer research paper
This is attributed to a decrease in Helicobacter pylori infection and the use of refrigeration to preserve foods rather than using salt. The combination of chemotherapy, radiation therapy, and surgery may reduce the chance that stomach cancer will return.
In this population of patients, endoscopic surveillance is recommended. Abstract Gastric cancer is an aggressive disease that continues to have a daunting impact on global health. Helicobacter pylori VacA, a paradigm for toxin multifunctionality. Classification of gastric cancer Sporadic gastric cancer The majority of GC occurs sporadically and mainly affects people over the age of 45 years. Newer chemotherapy chemo drugs are also being studied. About 70 per cent of cases of stomach cancer occur in less developed countries with about half of all cases in Eastern Asia, particularly China. Virchows Arch. Perhaps, the decline can be attributed in part to improved food preservation with the advent of electric refrigeration,[ 10 ] increased accessibility to fresh fruits and vegetables year round, lower salt diets less salt preservation , the decreased use of tobacco[ 11 ] and eradication of Helicobacter pylori infections in endemic areas. Globally, overall incidence rates of stomach cancer are declining. Drug combinations work slightly better than single drugs.
Some studies have found that treating this infection may prevent pre-cancerous stomach abnormalities, but more research is needed. The Asian countries account for the majority of the world's cases while Europe and the Americas combined makeup less than a quarter of the world disease burden.
Estimates of cancer incidence and mortality in Europe in Pembrolizumab is an immune checkpoint inhibitor and targets PD-L1, a protein found on some stomach cancer cells.
Doctors are also looking at giving both radiation therapy and chemotherapy before surgery.
Stomach cancer treatment
The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. Doctors can remove these lymph nodes and look for cancer. The next section in this guide is Coping with Treatment. This drug is already FDA-approved to treat some other cancers. Eur J Cancer. Helicobacter pylori infection Recent studies have shown that certain types of H pylori especially the cagA strains are more strongly linked to stomach cancer. The pathogenesis of cardia cancer is less well established, although it is associated with inflammation of the cardia. Recent research in countries with relatively low stomach cancer risk has provided some insight into risk factors. Abstract Gastric cancer is an aggressive disease that continues to have a daunting impact on global health. Treatment Chemotherapy drugs and combinations Some studies are testing new ways to combine treatments already known to be active against stomach cancer or other cancers.
Global cancer statistics. Researchers are looking at the genetic changes in tumor cells to identify specific genes, proteins, and other factors unique to the tumor.
Gastric cancer review 2017
There is a 15—fold variation in risk between the highest- and the lowest-risk populations. Schistosomes, liver flukes and Helicobacter pylori. For example, S-1 is an oral chemo drug related to 5-FU. Electric refrigerator use and gastric cancer risk. As such, the intestinal subtype is linked to the decreasing incidence in gastric cancer seen globally over the last several decades. This review briefly summarizes the most important aspects of gastric cancers, which include epidemiology, risk factors, classification, diagnosis, prevention, and treatment. This article has been cited by other articles in PMC. Clinical trials are underway to find better ways of reducing symptoms and side effects of current stomach cancer treatments to improve comfort and quality of life for patients. Within all afflicted nations, noncardia gastric cancer is more likely to affect persons of lower socioecomonic groups. If no cancer is found in these lymph nodes, then the cancer is unlikely to have reached others, and a full lymph node removal might not be needed. Time trend and age-period-cohort effects on gastric cancer incidence in Zaragoza and Navarre, Spain. The next section in this guide is Coping with Treatment.
The current trials have looked at progression and regression of precancerous lesions with eradication of infection. Stomach cardia cancer occurs at the top part of the stomach closest to the oesophagus, and stomach non-cardia cancer occurs in all other areas of the stomach.
based on 110 review